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mitochondrial/ribosomal protein genes in scRNA-seq analysis
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15 months ago
chipolino • 40

Hi everyone,

According to this tutorial, during the first steps of scRNA-seq analysis (normalization, dimensionality reduction, and finding DE genes), you should remove all mitochondrial/ribosomal protein genes.

But I also heard from other experts that it's a bad idea and you should not do it before dimensionality reduction and clustering, because tossing them out you're just compromising your ability to resolve clusters.

So should I remove mitochondrial and ribosomal protein genes before any further analysis or not?

Is there a correct answer to this question?

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