This is a test version of Biostars. For the public version, visit https://www.biostars.org.
How to interpret the eQTLs in cancer

According to the paper PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types, they conducted the eQTL mapping using RNA-seq and genotype data from TCGA.

I am a bit confused about the meaning of cancer eQTL. I know that an eQTL is a locus that explains a fraction of the genetic variance of a gene expression phenotype, so the eQTLs identified from cancer (and normal?) samples are the loci that may lead to gene expression disturbance during tumor transformation and development?

rna-seq snp eqtl tcga
• 2,430 views • link
updated by cao510927 • cao510927 • written by darklings darklings

i think you are right. The paper used the tumor and matched normal data to identify somatic mutation and evaluated the effects on the tumor sample gene expression.

• 0 views • link
written by cao510927 • cao510927

Oh wow thanks, now I am a bit confused about why I asked this question at that time...

• 0 views • link
written by darklings darklings

0 answers

No answers yet.

Log in to answer this question.

More posts like this