Lots of chip regions with high GC content and low sequence depth were detected

Dear All. In human genome panel sequencing, we found that some chip regions with high GC content were enriched in low sequence depth parts. So, My question is anyone knows how to explain this abnormal situation. Thanks.

gc content human genome ngs

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written 7.7 years ago by cginsea •

You should read about GC bias in next-generation-sequencing.

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written 7.7 years ago by ATpoint

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