Am trying to find the pathogenicity of a set of variants (by using ACMG guidelines: https://www.ncbi.nlm.nih.gov/pubmed/25741868 ). The vcf file of the variants looks like this:
CHROM POS ID REF ALT GT
22 11005678 . G A 0|1
22 16052167 . A AAAAC 0|1
I went through the paper but did not find a clear idea - could you please let me know the steps to predict the pathogenicity of such variants?