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Can anyone help me with Kimura 2 parameter model

Please explain me how we have got eq 3.17 from eq 3.16 [1] I am new to evolutionary biology with no math background thus facing problem. I have been able to solve till 3.16 but stuck after that.

Looking for positive reply

Thanks in advanvce

This is not bioinformatics, but calculus. The last step has to do with Leibniz's notation, check wiki if that sounds unfamiliar.

Thanks a lot.. i will have a look at it :)