Any tools for co-mutation analysis just like WGCNA on co-expression analysis

I know that WGCNA is widely used in co-expression analysis. I have a number of tumor samples and try to find significantly co-occurrent mutation across samples. My assumption is that certain combination of mutations is pathological.

I am not sure if WGCNA can be used for co-mutation. Is there any method for such analysis? Beside, I imagine that such co-mutation is usually sparse results. Do I need large amount of samples accordingly?

mutation expression

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written 7.7 years ago by CY

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