Hi there,

I analyzed some publicly available exome-seq data, and do not have matched normal/germline.

I identified somatic mutation (VCF format), by setting high filtering threshold. Which tool can be used to predict significantly mutated genes from these list ? Previously i used genome-music to find signifiacntly mutated genes, which requires both tumor/normal samples, and i dont't have matcher normal. Which tools cam predict significant mutations without matched normal samples.
Thanks !