Can someone suggest the tool to Calculate Tumor Mutation Burden from VCF file
How to calculate TMB (Tumor Mutation Burden) from VCF file?. suggest some reliable tools
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Have you tried maftools ?
http://bioconductor.org/packages/release/bioc/html/maftools.html
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There is a similar thread in Biostars, please go through it. TMB Tumor Mutation Burden
I can find no direct tools to calculate TMB only from VCF files.