Mutations to use in mutational signature analysis
When performing mutational signature analysis with R packages such as deconstructSigs and SomaticSignatures, should all SNVs be used or just nonsilent SNVs?
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Kevin Blighe
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jc •
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jc •
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I believe the choice is yours. It would make intuitive sense to include missense mutations, though, and not intronic or intergenic variants. Basically, you use whatever you want to use.
Kevin
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