I am currently researching mutational signatures in Cancer genomes (see here for an explanation: http://cancer.sanger.ac.uk/cosmic/signatures ). I am using the DeconstructSigs package in R to analyze the data I have available. I was just wondering, do there exist other software for performing the same task that are seen as better? I know of the existence of the SomaticSignatures package but am unclear whether it is any better or worse than DeconstructSigs.
Any advice would be greatly appreciated!
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written
by
peterodonovan •
1 answer
There are few other tools. DeconstructSigs estimates loading of known signatures for every sample in the cohort. If you are interested in de-novo you could try EMu and Mutational Signature framework. Both from Sanger.
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