Hi guys, is there someone who can explain me the meaning of the sva output as from the sva R library? In other words I run svobj = sva(edata,mod,mod0,n.sv=n.sv) as here https://www.bioconductor.org/packages/release/bioc/vignettes/sva/inst/doc/sva.pdf but it is not clear to me the meaning of the three outputs: pprob.gam, pprob.b and the estimated surrogate variables. Are these last coefficients? Or what? In the help they say: pprob.gam: "A vector of the posterior probabilities each gene is affected by heterogeneity" (which type of heterogeneity?) sv: "The estimated surrogate variables, one in each column" (?? coefficients?) pprob.b: "A vector of the posterior probabilities each gene is affected by mod" (by the batch effect?)

Thank you in advance