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Does a no-normal pipeline exist for MuSiC?

Hi,

We have a large set of tumor-only WES data that we want to run music smg. However, it's unclear from the documentations on whether:

  1. Matched tumor-normal bam files are required for music smg per se,
  2. Running music bmr calc-bmr is necessary before running music smg, and
  3. I can use the output from music bmr calc-wig-covg instead of music bmr calc-covg as the input of music bmr calc-bmr.

I would like previous users to give us more insight on this. Thanks!

music

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