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NCBI map viewer fragile site are molecularly characterized or not.

Hello everyone

In NCBI map viewer, there reported 127 fragile sites. can anyone have the idea that the all the fragile site listed in NCBI map viewer, are only cytogenetically defined (based on cytoband position) or they are cytogenetically defined with molecular characterized? Molecular characterization means that they are cloned at sequence level.

genome gene sequencing
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updated by tdmurphy tdmurphy • written by rajesh rajesh

I'm not familiar with a map of fragile sites in NCBI's (now retired) Map Viewer. What organism, assembly, and map name are you looking at? Can you provide a link for what you're referring to?

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written by tdmurphy tdmurphy

1 answer

Those fragile sites correspond to a set of fragile site records defined by HGNC, and imported into NCBI Gene: https://www.ncbi.nlm.nih.gov/gene/?term=txid9606%5Borgn%5D+genetype_other%5Bprop%5D+fragile+site%5Bgene%2Fprotein+name%5D

They're only defined by cytogenetic locations and aren't placed at the sequence level.

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written by tdmurphy tdmurphy

Thanks, This information helps me alot..but some of these fragile site are also characterized at molecular level by FISH analysis.

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written by rajesh rajesh

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