Hi,
Is there any known literature about the average size(in bp) and amount(#count) of Enhancers and Promoters the genome has?
I want to use this info in order to say something about the chance that a mutation can occur on these elements. (not based on conservation) Since I have my own data set and want to compare it with actual reference values.
Thank you!
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written
by
osiemen •
2 answers
"Transcriptional control regions often contain multiple, autonomous enhancer modules that vary from about 50 bp to 1.5 kbp in size." (Blackwood et al 1998) "It is estimated that hundreds of thousands of enhancers exist in the human genome." (Penacchio et al 2013)
"Promoter length can vary from 100 to 1000 base pairs." (Sharan et al 2007)
I think so. I've read papers with similar numbers. If I come across one, I'll link it.
See this recent article.
In the loop: promoter–enhancer interactions and bioinformatics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142009/
But the size and amount depend upon many additional factors.
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