Obtaining hazard ratio from beta and chi-square values
I have used a program called Probabel to run a cox regression on genotype data (to look for association with disease status). My output file looks as follows contains beta_SNP_addA1, sebeta_SNP_addA1 and chi2_SNP_add.
Is there any way I can use these values to obtain P-values and Hazard ratios?
Many thanks.
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Kevin Blighe
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m98
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From the Cox regression model statistics, in order to obtain the hazard ratio, just get the exponent of the derived beta coefficient (using R Programming Language):
exp(beta_SNP_addA1)
To get the upper and lower 95% confidence intervals:
exp( c( (beta_SNP_addA1 - (1.96*sebeta_SNP_addA1)), (beta_SNP_addA1 + (1.96*sebeta_SNP_addA1)) ) )
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