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What is the difference between paired and unpaired and same.dir is true or false in Gage?

Hi Everyone

What is the difference between paired and unpaired and same.dir is true or false in Gage? I read the manual of gage but I still don't get it. If anyone can help me with a nice example. Gage will look for pathways any of my gene list are involved in, so what does it mean same direction or both, paired or not?

Thanks

rna-seq gage pathway analysis

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