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Directionality of KEGG/Reactome/Wikipathways
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15 months ago
chipolino • 40

Hi everyone,

Am I right that pathways in KEGG do not have a direction? What I mean by that is for example pathway "KEGG_APOPTOSIS" contains genes that can activate or down regulate apoptosis in cell, am I right? Or is it only those that can activate? What about Reactome/wikipathways?

Thanks

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15 months ago
h.mon 25k
Brazil

For KEGG, the whole pathway per se doesn't have a "direction", but when known, the effects of individual genes (activation, inhibition, and so forth) are shown. See Notation on the KEGG Pathway Map help page.

I suppose the same is true for Reactome and WikiPathways, including using a similar notation. See, for example, the Apoptosis pathway at WikiPathways (which, coincidentally, was Today's Featured Pathway).

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