How to calculate the mutual information (MI) between two sites on a protein sequence?
How to calculate the mutual information (MI) between two sites on a protein sequence? what I need is a standalone tool or python script. Thanks.
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Jean-Karim Heriche
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Bjoux •
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Bjoux •
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Mutual information is a concept from information theory that aims at quantifying how dependent two variables are. On multiple sequence alignments, it can be used to identify co-evolving sites and can be computed from the column entropy. This paper may be relevant. MI for alignments can be computed with the R package BioPhysConnectoR
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I don’t really understand what you mean by mutual information? Can you elaborate?