Hi,
Given physical protein protein interaction like String and KEGG pathway. I would like to know how many of KEGG pathways or signaling pathways exist in PPI network. Is there any tool to extract known pathways(either entire or partial) from PPI network ?
1 answer
See my answer to the following post:
C: Pathway annotation using sequence alignment
it gives KEGG links.
There are a lot of papers about ppi, try to search KEGG.
I’ve provided some necessary links in my post above:
But it is not quite clear whose proteins you study.
STRING may also be helpful.
There are some random examples below (I searched NCBI for “KEGG AND ppi”):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022245/pdf/1745-6150-9-5.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851814/pdf/1752-0509-7-S2-S8.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300222/pdf/pone.0116347.pdf
But this link https://omictools.com/ppis-category
is more general, it relates to many areas.
And look at the right panel - there are a lot of similar questions:answers there,
it may be helpful too.
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Your question is not clear. Are you asking if one can extract an ENTIRE pathway from a PPI network? Or are you looking for even PARTIAL pathways from a PPI network - if so, what threshold would you use for inclusion or exclusion? Please restate your question more clearly.
Either entire or partial is fine.