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Difference between ncRNA & non_coding in GENCODE

Hello Biostars,

What's is the difference between ncRNA & non_coding annotating in GENCODE?(https://www.gencodegenes.org/gencode_biotypes.html#)

If I search for a particular gene (with non_coding annotation) 'ENSG00000283122' (http://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000283122;r=6:144004916-144008262;t=ENST00000635591 ), it shows me its transcript ID also. Can I consider this as ncRNA?

I'm missing some biology here. Please help me out. Thank you :)

snp genome next-gen gene
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written by anu014 anu014

They are writing miRNA, misc_RNA, rRNA etc as 'Non-coding RNA predicted using sequences from Rfam and miRBase' . Aren't these ncRNA?

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written by anu014 anu014

Yes, they're subcategories.

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written by Emily Emily

I'm not sure I understand your question. ncRNA == non-coding. Non-coding RNA is transcribed so makes a transcript. What are you asking about?

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written by Emily Emily

Hi Emily, Thanks for the reply. :)

I was confirming about definition of 'non-coding' : "Transcript which is known from the literature to not be protein coding" . According to this definition, gene is getting transcribed but doesn't form protein. Isn't this same case as ncRNA (A non-coding RNA (ncRNA) is a functional RNA molecule that is transcribed from DNA but not translated into proteins. source : wiki)

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written by anu014 anu014

Is this the difference: 'non-coding' is transcribed till primary transcript & dies off whereas ncRNA is a mature RNA?

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written by anu014 anu014

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