Hi,
I did Survival Analysis on a Group of genes using TCGA( Thanks to Biostar) and found that some of them have very significant role based on P Values in some Cancers. Now I just wanted to relate these Genes with some other genes very relevant for some important pathways, although my studied genes are not directly part of these pathways. basically, I just wanted to see that if the expression of these genes has anything to do with ( up regulation and down regulation ) with a particular set of gene(s) Since I am pretty new to such sort of analysis then can some guide me what sort of things I could do for such cases.
Thanks
2 answers
Since you are working with human tissues, you have the EntrezIDs. Check out the SPIA package available on the Bioconductor website.
Thanks !! Is there any other tools or method or tutorials apart from this as well?
Thanks Najeeb
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2017 Paper with an R package relevant to this type of analysis:
Pathway enrichment analysis approach based on topological structure and updated annotation of pathway.