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Cufflinks should not hang with 10GB bam file. What computer are you using?
Its a ubuntu 16.10 with 16GB RAM. But not all 10GB bam file hangs. I think there is some problem in BAM file that is why i wanted to split
I think that it's okay to split the BAM file by chromosome and to then analyse them independently in Cufflinks. Take a look here: How To Split A Bam File By Chromosome