Question: Overdispersion for single cell RNA seq experiments
0
Entering edit mode

How can I deal with overdispersion in single-cell RNA seq experiments? especially regarding low counts?

ADD COMMENTlink 2.6 years ago ly.leifels • 0 • updated 23 months ago eric.kern13 • 150
Entering edit mode
0

For clustering, or differential expression, or something else entirely?

ADD REPLYlink 2.6 years ago
Devon Ryan
90k
Entering edit mode
0

for clustering genes into gene modules

ADD REPLYlink 2.6 years ago
ly.leifels
• 0
1
Entering edit mode

What have you tried so far? One sensible solution might be to try:

If those don't get you to where you need to be, then where's the gap? Do you think the estimates are off, and if so, why? Or maybe you just need more reliable quantification of uncertainty?

ADD COMMENTlink 23 months ago eric.kern13 • 150

Login before adding your answer.

Powered by the version 1.8