Filter RNA-seq matrix
Dear community,
I am using RNA-seq data for gene network analysis. In data pre-processing, I filter out genes with low expresion counts and genes with low coefficient of variance (CV). I found the CV on counts and logs-transformed values are quite different, which means the former is significantly larger than the later. Thus, which is better regarding CV filtering, on counts or log2-values?
Regards.
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zhang.jianhai •
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zhang.jianhai •
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Check what the manual of the tool you use recommends.