priors for calculting genotype likelihood using RNAseq data
Can anyone point me to a literature or explain the need of population priors during genotype likelihood estimation using RNAseq data? I did get results connected to DNAseq. I am using bcftools mpileup (v1.4) for likelihood estimation and then genotype calling and variant calling using bcftools call (v1.4).
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Why would variant calling on RNAseq be any different than that on DNAseq data in this respect?