B-Values and M-Values

Question

[A7C]

Hello all,

im an undergraduated student, and Im developing a project were the ideia is to relate methylation with gene expression in cancer, and see the outcome or even predict it. I'm using the 450k array from TCGA. The values that we can access are Beta values, but in many pappers they suggest us to use M-values. The thing is, Im not quite sure if i understood the meaning of the M-value, and how it can be better compered with B-value. Since b-values are more for biological aswers and M-values for statistical purpose, I'm confused about wich one is better for me to use. I'm starting to think that the problem is, that i dont really understand concept of M-value. If anyone could help, I appreciate.

Thank you all

Answer 1

[asyavuz]

You may start by reading this article. It will give you the necessary background in understanding why and when M-value should be preferred. You can easily calculate M-values from B-values or vice versa. And again, this paper has the necessary formulas in it.

Good luck!