Getting Precomputed Conservation Scores

Question

[GabrielMontenegro]

I have a list of millions of SNPs (rs IDs) and I wanted to know if these are highly conserved sites based on conservation metrics, for example: PhastCons, GERP or SiPhy scores.

I was trying to find precomputed scores for these metrics, but wasn't very successful at finding them. I could find precomputed conservation scores for the GERP metric, but I wanted to contrast these scores with others and that's why I was asking for help.

Thank you.

Answer 1

[Santosh Anand]

It will be easier to do it by using ANNOVAR filter-based annotation

http://annovar.openbioinformatics.org/en/latest/user-guide/filter/

You may use dbNSFP database of ANNOVAR for your current purpose. But there are many other DBs that might interest you, just have look.