Start by reading the literature involving detection of mitochondrial variants. ADD REPLY • 0 views • link written 9.9 years ago by Devon Ryan 10K
See these papers: Mitochondria sequence mapping strategies and practicability of mitochondria variant detection from exome and RNA sequencing data http://sci-hub.cc/10.1093/bib/bbv057# Performance of mitochondrial DNA mutations detecting early stage cancer http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-8-285 Accurate mitochondrial DNA sequencing using off-target reads provides a single test to identify pathogenic point mutations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272251/ But: Mitochondrial DNA exhibits resistance to induced point and deletion mutations. https://www.ncbi.nlm.nih.gov/pubmed/27550180 See also this posts: Where can I download a list of mtDNA haplogroup mutations? How To Get The Mutation List For Mtdna Complete Sequence Submitted In Genbank? - this one is rather old but may be useful ADD REPLY • 0 views • link written 9.9 years ago by natasha.sernova 399
where can i get the mutated and non mutated dataset of mtdna ?? if you know other then ncbi there because mutated dataset is not available there ADD REPLY • 0 views • link written 9.9 years ago by arpitagupta2993 0
You can try here: Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169240/ See Table S1. ADD REPLY • 0 views • link written 9.9 years ago by natasha.sernova 399
Start by reading the literature involving detection of mitochondrial variants.
See these papers:
Mitochondria sequence mapping strategies and practicability of mitochondria variant detection from exome and RNA sequencing data
http://sci-hub.cc/10.1093/bib/bbv057#
Performance of mitochondrial DNA mutations detecting early stage cancer
http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-8-285
Accurate mitochondrial DNA sequencing using off-target reads provides a single test to identify pathogenic point mutations
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272251/
But:
Mitochondrial DNA exhibits resistance to induced point and deletion mutations.
https://www.ncbi.nlm.nih.gov/pubmed/27550180
See also this posts:
Where can I download a list of mtDNA haplogroup mutations?
How To Get The Mutation List For Mtdna Complete Sequence Submitted In Genbank? - this one is rather old but may be useful
where can i get the mutated and non mutated dataset of mtdna ?? if you know other then ncbi there because mutated dataset is not available there
You can try here:
Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169240/
See Table S1.