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MtDNA Mutation Detection

I am a CSE student doesn't know much about bioinfomatics but i am trying to make a mtdna mutation detection project can anyone help me with any idea how to do that???

gene
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updated by WouterDeCoster WouterDeCoster • written by arpitagupta2993 • arpitagupta2993

Start by reading the literature involving detection of mitochondrial variants.

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written by Devon Ryan Devon Ryan

See these papers:

Mitochondria sequence mapping strategies and practicability of mitochondria variant detection from exome and RNA sequencing data

http://sci-hub.cc/10.1093/bib/bbv057#

Performance of mitochondrial DNA mutations detecting early stage cancer

http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-8-285

Accurate mitochondrial DNA sequencing using off-target reads provides a single test to identify pathogenic point mutations

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272251/

But:

Mitochondrial DNA exhibits resistance to induced point and deletion mutations.

https://www.ncbi.nlm.nih.gov/pubmed/27550180

See also this posts:

Where can I download a list of mtDNA haplogroup mutations?

How To Get The Mutation List For Mtdna Complete Sequence Submitted In Genbank? - this one is rather old but may be useful

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written by natasha.sernova natasha.sernova

where can i get the mutated and non mutated dataset of mtdna ?? if you know other then ncbi there because mutated dataset is not available there

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written by arpitagupta2993 • arpitagupta2993

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