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Are there any software for the alignment-free bacterial whole genome sequence similarity search and comparison?

Are there any working software (s) for the alignment-free bacterial whole genome sequence similarity search and comparison? Thx.

wgs vcf alignment similarity sequencing

1 answer

If all you want is a tree via evolutionary distances, there are plenty of tools available:

  • andi (shameless self-plug ☺)
  • spaced words
  • mash
  • co-phylog
  • kr, alfred, missmax, aff, csc, skrakov-phy, …

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