Does the result of Gistic pipeline of Firehose generated by different runs are large different?
I 'm trying to reproduce Copy Number Variations(CNV) data in a form of Sample-Event Call Matrix of this paper(Ciriello G, et al. Nature genetics, 2013)
But after processing all significant CNV regions generated by recent firehose Gistic run, the CNV regions are large different from those regions in paper which also generated by Firehose but preprevious run （before 2013）. I guess the difference may be caused by different Firehose runs.
Does the result of Gistic pipeline of Firehose generated by different runs are large different ? Is it reasonable to get very different results of two runs of firehose's Gistic pipeline?
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Feng Xie •
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