You will need to save the file in some delimited format. Add -d option if you use a different delimiter (-d',') You can put this command in a loop to get all column combinations.
$ cut -f 1,2 your_file > col_1_2
$ cut -f 1,3 your_file > col_1_3
$ cut -f 5,6 your_file > col_5_6
You can use awk to print the columns in any order you wish (if file is not tab delimited change \t delimiter)
$ awk -F '\t' '{print $6"\t"$3"\t"$2}' your_file > new_file_col_6_3_2