Hello All

I am trying to process my Illumina 450 K methylation array data using Minfi but I keep getting the following error after using the function dmpFinder.

Error in smooth.spline(lambda, vec.p0, w = ncs.weights, df = 3) :
  missing or infinite values in inputs are not allowed
In addition: Warning message:
Partial NA coefficients for 9542 probe(s)

I have tried removing the NAs, used beta threshold, tried different preprocessing methods etc. but nothing seems to work. I am fairly new to R. Any help would be highly appreciated.

Thanks