Multiple transcripts encoding for one protein
Trying to get a better understanding of the process of DNA to proteins.
So when we have a gene, it is read from the 5' to 3' end, only reading the exons. A single gene can have multiple exons, and use alternative splicing to create different transcripts. A transcript may result in mRNA (not necessarily right? Also other kinds of RNA?) which is translated to amino acids. Finally folded to a functional protein.
My question here, are there different transcripts (say in different genes) that encode for the same protein?
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Danielson •
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Hello Danielson!
We believe that this post does not fit the main topic of this site.
This is basic biology, not related to bioinformatics. Answer is yes: != transcript can encode same protein: e.g: alternative splicing with a non-translated exon
For this reason we have closed your question. This allows us to keep the site focused on the topics that the community can help with.
If you disagree please tell us why in a reply below, we'll be happy to talk about it.
Cheers!
Then I don't understand what the boundaries of bioinformatics are. You need information on the biology itself, otherwise you are just doing informatics... You must make assumptions, based on what is presumed to be correct. If you look at the Ensembl database you see that one transcript (at most) links to one protein. If I were to presume that to be by definition (which is where the question is about), then I would make a 1-n relation whereas it should have been a m-n relation.
I don't understand your answer
Answer is yes: != transcript can encode same protein.!=means does not equal. But alternative splicing does not result in different transcript (as far as I understand) because a specific form of splicing is a transcript, but from a single gene...While you need to be knowledgeable in biology to do bioinformatics, not all biology questions are appropriate on a bioinformatics site. Yours, for example, is just a basic biology question, so it's appropriate on a general biology site, but not a bioinformatics site (or other specialized site, like one on neuroscience, or protein folding).