I am trying to run the program here: http://dasan.sejong.ac.kr/~wikim/notice.html

In one of the .java files, it makes a call to the blastp function in the NCBI blast+ package.

 public ArrayList runBlast(String query, String subject) {
    ArrayList scoreList = new ArrayList();
    Runtime rt = Runtime.getRuntime();   
    subject = ParaNames.Species+subject;
    try { 
    Process proc = rt.exec(new String[] **{"~/Downloads/ncbi-blast-2.2.30+/bin/blastp", "-query", query, "-subject", subject, "-num_threads", "4", "-matrix", matrix, "-outfmt", "10 qseqid sseqid score"})**;
       InputStream is = proc.getInputStream();
       InputStream es = proc.getErrorStream();
       BufferedReader reader = new BufferedReader(new InputStreamReader(is));   
       BufferedReader readerError = new BufferedReader(new InputStreamReader(es));
       String line; 
       while ((line = reader.readLine()) != null) {
        scoreList.add(line);  
       }
       if (proc.waitFor() != 0) {
         System.err.println("Process exited with (normal termination: 0) "+proc.exitValue());
         System.err.println("Error: "+readerError.readLine());
       }
       is.close(); is = null;
       es.close(); es = null;
       reader.close(); reader = null;
       readerError.close(); readerError = null;
       proc.destroy(); proc = null;
    } 
    catch (InterruptedException e) {   
         System.err.println("Error: "+e.getMessage());   
    }
    catch (IOException ioe) {
    System.err.println("Failed to execute: "+ioe.getMessage());
    }

    return scoreList;
  }

I have downloaded ncbi-blast-2.2.30+ and it is in the Downloads folder.

When I run this however, I am getting the following error:

May 20, 2015 1:40:33 PM ReMark.RecursiveClustering <init>
INFO: Trying to run BLAST now - this may take several hours ... or days!
May 20, 2015 1:40:33 PM ReMark.RecursiveClustering <init>
INFO: Starting ortholog detection...................................
Failed to execute: Cannot run program "~/Downloads/ncbi-blast-2.2.30+/bin/blast": error=2, No such file or directory
Failed to execute: Cannot run program "~/Downloads/ncbi-blast-2.2.30+/bin/blast": error=2, No such file or directory
Failed to execute: Cannot run program "~/Downloads/ncbi-blast-2.2.30+/bin/blast": error=2, No such file or directory
Failed to execute: Cannot run program "~/Downloads/ncbi-blast-2.2.30+/bin/blast": error=2, No such file or directory
Failed to execute: Cannot run program "~/Downloads/ncbi-blast-2.2.30+/bin/blast": error=2, No such file or directory

Could someone explain what I need to do to fix this? I can provide any other information you need. Thank you very much.