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Null and alternative hypothesis being tested in SAM

Hello all,

I come from a statistical background and I recently started doing work for a bioinformatics research centre. I was wondering if someone could clarify what the null and alternative hypotheses are being tested in SAM (significance analysis of microarrays) in terms of two-sided, one-tailed up, and one-tailed down. Particularly, I'm working on csSAM (cell specific SAM).

statistics sam significance testing hypothesis

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