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endoplasmic reticulum membrane size

Hi,

I have a question about the endoplasmic reticulum membrane. what is the size of it?

er biology
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updated by Ram Ram • written by a.polo88 a.polo88

"Size" is a bit ambiguous, so if you are not looking for the membrane thickness, and rather some other length dimension or another measure such as density or volume, please rephrase.

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written by Keith Callenberg Keith Callenberg

Hello a.polo88!

We believe that this post does not fit the main topic of this site.

off topic, no relation to bioinformatics, pure biology questions can go to biology.stackexchange.com

For this reason we have closed your question. This allows us to keep the site focused on the topics that the community can help with.

If you disagree please tell us why in a reply below, we'll be happy to talk about it.

Cheers!

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written by Michael Dondrup Michael Dondrup

Hello,

My question is a biological question, right. But the question is related for a bioinformatics contest. Why? because there are many bioinformatics software i.e., gromacs, VDM that give the possibility to construct the membrane to reproduce the contest of transmembrane proteins. I had the necessity to know if anyone can help me. but yes this is a biological question and I'm sorry.

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updated by Ram Ram • written by a.polo88 a.polo88

Thanks for the additional information. Normally, it would be sufficient if the connection to bioinformatics or computational biology is made evident, but this should happen in the original post and is the responsibility of the OP to show, meaning we shouldn't have to guess. If the intention of asking a pure biology question is to confirm a comp. biology prediction or to set parameters in a modelling tool accordingly, be my guest. However that would still be borderline, wouldn't it? Requesting comments.

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written by Michael Dondrup Michael Dondrup

I mean what you say and thanks to explain me this. so I overcome to ask bad questions in future. For me its ok i received a good answer fromm Keith.

best regards

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written by a.polo88 a.polo88

1 answer

The thickness of the endoplasmic reticulum was measured in one context (rat hepatocytes) to be 37.5 angstroms.

Mitra, K., I. Ubarretxena-Belandia, T. Taguchi, G. Warren, and D. M. Engelman. 2004. MODULATION OF THE BILAYER THICKNESS OF EXOCYTIC PATHWAY MEMBRANES BY MEMBRANE PROTEINS RATHER THAN CHOLESTEROL. Proc. Natl. Acad. Sci. U.S.A., 101:4083-4088. http://www.pnas.org/content/101/12/4083

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updated by Ram Ram • written by Keith Callenberg Keith Callenberg

thanks good article

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written by a.polo88 a.polo88

Do note that rat hepatocyte may not be representative of mouse cells or human cells or rat myocyte or anything else.

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updated by Ram Ram • written by karl.stamm karl.stamm

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