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What is the name of an article which is against the "The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity"

Hello:

I am find an article where its opinion is against "The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity".

Could anynone tell me the name? Thanks!

ccle
• 2,918 views • link
updated by Ram Ram • written by zero_hsy zero_hsy

Give a bit more detail, as it depends which aspect of the paper you want to criticise:

  • precision medicine as a whole;
  • the relevance of cell line studies to in vivo drug sensitivity;
  • the relevance of cell lines as a model of tumours;
  • that genomic markers can be mapped to metabolism;
  • the choice of drugs, cell-lines and/or markers, and potential biases therein, used by ccle;
  • the prediction methods used;
  • the quality of the dataset;

that the results don't match exactly with those that you have obtained in the same cells ;)

...

In fact, it might be easier for you to just write a critique yourself

• 0 views • link
updated by Ram Ram • written by russhh russhh

Thanks a lot.It is a paper which contains the gene expression data on the probably 600 cell lines. And its opinion is against the above article.

• 0 views • link
written by zero_hsy zero_hsy

1 answer

I think you are looking for this:

1: Haibe-Kains B, El-Hachem N, Birkbak NJ, Jin AC, Beck AH, Aerts HJ, Quackenbush
J. Inconsistency in large pharmacogenomic studies. Nature. 2013 Dec
19;504(7480):389-93. doi: 10.1038/nature12831. Epub 2013 Nov 27. PubMed PMID:
24284626; PubMed Central PMCID: PMC4237165.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237165/

• 0 views • link
updated by Ram Ram • written by coldrecd coldrecd

Thanks a lot !!

• 0 views • link
written by zero_hsy zero_hsy

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