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Read through genes
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14 months ago
cdsouthan ♦ 1.8k

Folowing up on the announcment for release 79 I did my occasional check of the human stats. We see "20,300 (incl 519 readthrough)" but is there any evidence that these read through transcripts are producing read through protein chimeras ?

Ensembl • 604 views
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Note, the answer is "yes there is evidence of this", but I'm having a heck of a time finding a recent example of this that I saw. I'll continue looking...

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So we would expect 519 TrEMBL IDs for the fusion proteins ?

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Presumably, but Emily would be the better person to ask.

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13 months ago
EMBL-EBI

Go to the supporting evidence page for a transcript to find out.

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So we would expect 519 TrEMBL IDs for the fusion proteins ?

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13 months ago
Freiburg, Germany

Ah, I finally found an example of this: TUBB3 and MC1R. I haven't checked to see if these are annotated as being read-through in the most recent build, but they should be. BTW, this is a great example of "biology is messy" :)

Edit : BTW, I only new of this due to this thread.

Edit2 : Interestingly, this isn't annotated as being read through in the newest build. I suspect this is an over-site, since TUBB3 and MC1R have their own annotations and then there's a separate ID for the fusion gene (though it's also labelled TUBB3).

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