hello frnds.. i m new in this field. can anybody tell me what is exact meaning of fold enrichment and what can we find out by knowing this? thanks you.
•
written
by
Manish •
2 answers
You could possibly be talking about Fold enrichment in terms of:
number of genes found in list X with a certain GO term
divided by
number of genes expected (based on size of list and number of genes in genome with GO term)
A lot of times people do a hypergeometric or fisher's exact test to find significantly enriched GO terms, then make a plot or table listing the fold enrichment for each term.
That would mean that you have 3 times as many genes annotated with that term as you would expect given the size of your gene list and the number of genes annotated with that term in the genome.
Where did you stumble on that term? It is indeed not very clear.
Since you mention gene-ontology in the title and tags you are probably looking at methods that look for enrichment of genes that meet a certain condition and to a specific GO term. That condition in gene expression experiments will often be a fold change.
Log in to answer this question.
-
detecting UMIs barcodes
written by annaA •
-
Articles that explain about PI_HAT and Z0 Z1 Z2
written by m.tonetti03 •
-
raxml - definition of site
written by estranged22 •
-
Low-pass whole genome sequencing
written by nazaninhoseinkhan
-
Significant genes in RNA-seq
written by faqrulhasan10225 •
-
how to design biological pathways
written by kartikayprasad •
-
Finding instances of motifs near peaks
written by Prakash
-
Rna seq data analysis beginner
written by jeccy.J
-
Rna Folding Structure And Target Identification
written by Manish •
-
Orthologus Genes
written by Manish •
Basic aspects of gene ontology enrichment analysis are discussed here.
thanks for suggestion.