How to download human whole genome database?

Question

[Ginsea Chen]

Hello everyone

I want to download gene model and annotation files of human whole genome, but I can't find more links can be used except ensembl, and files download from ensembl contained many shorter sequences (e.g 5-10 amino acid sites). So I want to find another available links, if you have downloaded before, please give me some suggestions, thank you!

Answer 1

[Brian Bushnell]

You can get the chromosomes here:

ftp://ftp.ncbi.nlm.nih.gov/genomes/H_sapiens/Assembled_chromosomes/seq/

If you look in the nearby subdirectories of ftp://ftp.ncbi.nlm.nih.gov/genomes/H_sapiens/, there are annotations and other things.

This file should help: ftp://ftp.ncbi.nlm.nih.gov/genomes/H_sapiens/README

...but it's still a bit confusing. You probably want the files for hs_ref_GRCh38.