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SILAC data normalization

How is normalization for differences in amount of protein across Light/medium/heavy samples made in SILAC data generated by Maxquant?

silac

1 answer

I apologize for not tracking down the official SILAC citation, but within the recent 2014 Cox et al. paper on LFQ, there is a brief mention that a similar normalization approach is taken with SILAC data (both are precursor quant so this isn't too much of a stretch). I assume a better reference is within.

EDIT: I would also post this question on the MQ google group, since Jürgen (or someone else from MQ) will answer questions. This week is MQ summer school, so maybe not a super quick response.

thanks. I will read into it.

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