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ELISA data QC and normalization

Greetings!

I am doing a meta-analysis of ELISA data. Having never generated my own ELISA data, I'm wondering:

1) The data are very highly skewed / log-normal. Is this typical, or does this indicate issues with data quality?

2) Is there a standard procedure/pipeline for quality control and data normalization? There seem to be large differences across studies for the same analyte in similar populations.

Thank you!

elisa metaanalysis

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