This is a test version of Biostars. For the public version, visit https://www.biostars.org.
I need help clustering genes across different timepoints AND multiple tissues

I am an intern tasked with a project.

I have a dataframe of approximately 200 genes in 7 tissues, showing the correlation of their expression across various timepoints. My next step is to find which genes have similar expression patterns in all of the tissues. AI tells me that hierarchal clustering would be the best method, but I couldn't find/understand anything on Google. Im not sure if I should flatten my data (e.g. Tissue_timepoint, Brain_P1) and do normal k means clustering, as I have read that it results in some loss in information. Any advice or links to resources would be appreciated.

advice help clustering

To me it is not clear how your data looks like. You say you have 200x7 dataframe, but is it for one timepoint? If not, then how many timepoints you have?

Irrespective, did you first try doing PCA to see how it looks?

0 answers

No answers yet.

Log in to answer this question.