Neurodegenerative disorders linked to protein dysfunction are difficult to study because of the complexity of the underlying molecular interactions. A great example is TAR DNA-binding protein 43 (TDP-43), found in diseases like amyotrophic lateral sclerosis (ALS), Parkinson's disease and several types of dementia. Today, researchers are still trying to answer how TDP-43's activity translates into broader cellular effects.

In this webinar, we will explore how to combine CRISPR-based screening approaches and pathway-level analysis for biological interpretation that encompasses more than gene-level observations. Using QIAGEN Ingenuity Pathway Analysis (IPA), we will demonstrate strategies to contextualize screening results and assess the functional relevance of candidate modifiers within cellular networks.

You will learn:

• About the role of TDP-43 in the cell and its connection to neuropathies
• How to investigate CRISPR screen hits using IPA
• How to validate the rescue effect of genetic modifiers using pathway activation scores

Registration here: https://digitalinsights.qiagen.com/webinars-and-events/target-discovery-in-alzheimers-linking-causal-biology-with-cns-expression-2/?cmpid=ADMWEB

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