Hi, everyone

When performing enrichment analysis using ORA, even when using the same DEGs, background set, and statistical method, the results are highly discrepant between g\:Profiler (gost) and clusterProfiler (enrichGO). Even when using genORA, the results are similar to clusterProfiler but still differ significantly from gost. The discrepancy exceeds threefold when analyzing the same gene set. What could explain this difference? Which package should be considered more reliable?

Thanks