I am working to design aptamer using computational tools. I am finding difficulty in designing of aptamer sequence from scratch. Anybody can suggest me tools/software to design aptamer sequence.
To my best knowledge, there is still always an experimental SELEX step involved. Synthesizing random oligo pools is by now probably way cheaper than computationally simulating the folded 3D-structure of tens of thousands of sequences?
But quickly screening the literature on Pubmed brought up some freely accessible articles that could be helpful:
(computer simulation[MeSH Terms]) AND ((Aptamers, Nucleotide[MeSH Terms]) OR (SELEX Aptamer Technique[MeSH Terms]))
Hello I was in the process of designing PCR primers. On the Exon 3----(2326..2824)= 499 bp .........of Human SERPING1 gene I used this sequence (downloaded …
Hi, I am using RNA-Seq data from ArrayExpress and I'm having difficulty finding out whether its necessary to use some software to remove adapter sequences. …
Hi all, I am looking command line tools for finding motifs in nucleotide sequence using ONLY gene list (Not binding data, chipseq etc...). Please suggest …
<p>Can anybody suggest a C++ book that describes the applications of the C++ programme in bioinformatics/ computational biology tools like sequence alignment etc.? Thank you …
To my best knowledge, there is still always an experimental SELEX step involved. Synthesizing random oligo pools is by now probably way cheaper than computationally simulating the folded 3D-structure of tens of thousands of sequences?
But quickly screening the literature on Pubmed brought up some freely accessible articles that could be helpful: