Hi, I have WES data from **precancer lesions and paired tumors** needed to estimate tumor purity and ploidy. Crucially, **I do not have match normal …

Hello everyone, I'm seeking feedback on my pipeline for detecting somatic variants and rare germline mutations associated with a rare type of cancer. Unfortunately, I …

Hi all, I have Whole Exome Sequencing data for multiple tumour samples but do not have matched normal or non-matched normal samples. Are you aware …

Hi Everyone, What are the best tools for CNV variant calling in the context of whole exome sequencing (WES) analysis? I'm currently working on a …

hello. Now I'm using the Varscan2 to see CNV from whole exome sequencing data. However, Some of my samples are not matched. I just have …

Hello all, I'm a bit confused as to what steps are necessary, and what steps are not going to add much benefit. I have 2 …

Hi all, I would like to check the presence of germline CNV in my samples. I wonder what are the best germline CNV callers using …

I want to use cnvkit to call copy number alterations (CNAs) from Whole Exome Sequencing data (WES) of a specific tumor. I have a set …

Hi, I am looking for the current state-of-the-art tools/practices for CNV (structural variation) detection/analysis for family (trio) data produced by Illumina. I will have data …

<p>What are currently the best copy number variantion calling tools? </p> <p>Is there a distinction between the best tools suited for whole genome or exome …