Advisable to perform GSVA on single cells?
Hi all,
I am currently working on a scRNA-seq dataset with 6K cells and I have been asked to perform a GSVA analysis on single-cells. After researching this a little, I could not find any online resources for performing a GSVA on individual cells (other than some wrappers). My question is: Is it advisable to perform a GSVA on single cells (from a statistical perspective), and if yes, then how would you design your workflow?
In addition, I am not sure if the kernel I should use should be Gaussian or Poisson. Could someone please advice me about this?
Thank you and have a lovely weekend!
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