Low Coverage WGS (Human) vs WES Hardware Requirements
Hello,
I'm trying to practice on my laptop (M1 Pro) the variant calling process. I'm practicing with data from the 1000 genome project, with the file ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR062/SRR062634/SRR062634_1.fastq.gz, which is categorize as LOW COVERAGE WGS, it isn't specified the exactly coverage. The size of the file is 3GB approx., which is the same as a whole exome sequencing file. My question is, since I was able to complete the variant calling analysis with a low coverage WGS file, is it correct to assume my computer will be able to run a sample from a WES (1 sample)?
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GenoMax
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rodrigo.sanchez •
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Why not try an example out? You don't say how much RAM you have or what exactly you did to call the variants but if it worked with a data file of similar size it may work with WES data.