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imputation A1, A2

I performed imputation using Minimac4, and I noticed that some SNPs have their ref and alt alleles swapped. I believe this is due to the Minor Allele Frequency (MAF).

Is it possible for 20% of the SNPs to exhibit this phenomenon?

ex) 1:131124:A:G , ref = G, alt = A

Thank you.

a1 imputation a2 gwas

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